⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22866556 | 1.00 | — | — | |
| SCHEMBL21718458 | 0.86 | HPGD (0.32) | — | |
| SCHEMBL19778533 | 0.83 | GRM4 (0.30) | — | |
| SCHEMBL29698226 | 0.83 | GRM4 (0.30) | — | |
| SCHEMBL31310111 | 0.78 | GAA (0.33) | — | |
| SCHEMBL31345073 | 0.73 | — | — | |
| SCHEMBL502743 | 0.73 | — | — | |
| SCHEMBL31310126 | 0.72 | ALDH1A1 (0.47) | — | |
| SCHEMBL23832865 | 0.71 | GAA (0.30) | — | |
| SCHEMBL933090 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269756-B | 4-Oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds that inhibit EIF4E | 效应疗法股份有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-114269756-A | 4-oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds inhibiting EIF4E | 效应疗法股份有限公司 | 2022-04-01 | — | — | CN | disclosed |