Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GHSR | Q92847 | 1/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22776343 | 1.00 | TRPV1 (0.51) | TRPV1CA12CA1CA2CA7 | |
| SCHEMBL29560706 | 0.90 | TRPV1 (0.52) | TRPV1CA12CA1CA2CA7 | |
| SCHEMBL29560518 | 0.89 | TRPV1 (0.48) | TRPV1CA12CA1CA2CA7 | |
| SCHEMBL30710453 | 0.88 | TRPV1 (0.43) | TRPV1CA12CA1CA2CA7 | |
| SCHEMBL29561032 | 0.87 | TRPV1 (0.53) | TRPV1CA12CA1CA2CA7 | |
| SCHEMBL22776272 | 0.84 | TRPV1 (0.53) | TRPV1CA12CA1CA2CA7 | |
| SCHEMBL30965934 | 0.84 | CHRM3 (0.61) | TRPV1CHRM3KCNH2TRPM8 | |
| SCHEMBL29561886 | 0.83 | TRPV1 (0.47) | TRPV1CA12CA1CA2CA7 | |
| SCHEMBL29560909 | 0.81 | GHSR (0.54) | TRPV1CHRM3KCNH2GHSR | |
| SCHEMBL30710436 | 0.80 | TRPV1 (0.47) | TRPV1CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113950477-B | Granulin precursor modulators and methods of use thereof | 阿库达医疗公司 | 2024-07-05 | — | — | CN | disclosed |
| EP-3983401-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | Arkuda Therapeutics (US) | 2022-04-20 | — | — | EP | disclosed |