Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22831802 | 1.00 | BRAF (0.33) | BRAFMEN1KMT2AMAPTLMNA | |
| SCHEMBL22831987 | 0.93 | BRAF (0.35) | BRAFMEN1KMT2AMAPTLMNA | |
| SCHEMBL22831818 | 0.87 | BRAF (0.35) | BRAF | |
| SCHEMBL22831947 | 0.86 | BRAF (0.33) | BRAFKMT2AARALDH3A1 | |
| SCHEMBL22832125 | 0.80 | BRAF (0.36) | BRAF | |
| SCHEMBL31150404 | 0.80 | BRAF (0.45) | BRAF | |
| SCHEMBL29561773 | 0.80 | LMNA (0.36) | MEN1KMT2AMAPTLMNAALDH3A1 | |
| SCHEMBL22832028 | 0.80 | LMNA (0.36) | MEN1KMT2AMAPTLMNAALDH3A1 | |
| SCHEMBL22831801 | 0.80 | BRAF (0.40) | BRAFMAPT | |
| SCHEMBL30353776 | 0.79 | TDP1 (0.36) | MEN1KMT2AMAPTLMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3990437-A1 | QUINAZOLIN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS | Array Biopharma, Inc. (US) | 2022-05-04 | — | — | EP | disclosed |