Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 1.00 |
| ▸ | EGFR | P00533 | 14/20 | 0.82 |
| ▸ | KDR | P35968 | 14/20 | 0.82 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.82 |
| ▸ | FLT1 | P17948 | 9/20 | 0.82 |
| ▸ | FLT4 | P35916 | 9/20 | 0.82 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.82 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.82 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.82 |
| ▸ | TEK | Q02763 | 2/20 | 0.82 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.82 |
| ▸ | PLK4 | O00444 | 1/20 | 0.82 |
| ▸ | CIT | O14578 | 1/20 | 0.82 |
| ▸ | GAK | O14976 | 1/20 | 0.82 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.82 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.82 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.82 |
| ▸ | STK10 | O94804 | 1/20 | 0.82 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.82 |
| ▸ | ABL1 | P00519 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10102554 | 1.00 | RET (1.00) | RETEGFRKDRFGFR1FLT1 | |
| SCHEMBL12604711 | 0.91 | RET (0.84) | RETEGFRKDRFGFR1FLT1 | |
| Vandetanib SCHEMBL4637084 | 0.91 | EGFR (0.98) | RETEGFRKDRFGFR1FLT1 | |
| SCHEMBL13458986 | 0.90 | RET (0.82) | RETEGFRKDRFGFR1FLT1 | |
| SCHEMBL4544070 | 0.90 | EGFR (0.87) | RETEGFRKDRFGFR1FLT1 | |
| Vandetanib SCHEMBL29352879 | 0.90 | EGFR (1.00) | RETEGFRKDRFGFR1FLT1 | |
| Vandetanib SCHEMBL28224661 | 0.90 | EGFR (1.00) | RETEGFRKDRFGFR1FLT1 | |
| Vandetanib SCHEMBL9044 | 0.90 | EGFR (1.00) | RETEGFRKDRFGFR1FLT1 | |
| Vandetanib SCHEMBL1614458 | 0.90 | EGFR (1.00) | RETEGFRKDRFGFR1FLT1 | |
| Vandetanib SCHEMBL1783178 | 0.88 | EGFR (0.89) | RETEGFRKDRFGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113616656-B | Heterocyclic compounds for the treatment of PI 3K-gamma mediated disorders | 无限药品股份有限公司 | 2023-02-17 | — | — | CN | disclosed |
| CN-109071647-B | Anti-growth differentiation factor 15 antibody and application thereof | 诺华股份有限公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-115066231-A | Synthetic tissue barrier and uses thereof | 麻省理工学院 | 2022-09-16 | — | — | CN | disclosed |
| CN-108430509-B | Antibodies that specifically bind TIM-3 and uses thereof | 詹森生物科技公司 | 2022-09-16 | — | — | CN | disclosed |
| CN-108697791-B | Antibodies that specifically bind to PD-1 and uses thereof | 詹森生物科技公司 | 2022-08-23 | — | — | CN | disclosed |
| CN-114920840-A | Antibody molecules against PD-L1 and uses thereof | 诺华股份有限公司 | 2022-08-19 | — | — | CN | disclosed |
| CN-114829447-A | Brush prodrug and use thereof | 麻省理工学院 | 2022-07-29 | — | — | CN | disclosed |
| CN-114727974-A | HDAC6 inhibitors and uses thereof | 艾科尼佐治疗股份有限公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-114555610-A | Boronic ester prodrugs and uses thereof | 麻省理工学院 | 2022-05-27 | — | — | CN | disclosed |
| CN-114502590-A | ENTPD2 antibodies, combination therapies, and methods of using these antibodies and combination therapies | 诺华股份有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-114478790-A | Antibodies that specifically bind to PD-1 and TIM-3 and uses thereof | 詹森生物科技公司 | 2022-05-13 | — | — | CN | disclosed |