Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.87 |
| ▸ | KDR | P35968 | 12/20 | 0.87 |
| ▸ | FGFR1 | P11362 | 11/20 | 0.87 |
| ▸ | FLT1 | P17948 | 11/20 | 0.87 |
| ▸ | FLT4 | P35916 | 11/20 | 0.87 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.87 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.87 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.87 |
| ▸ | TEK | Q02763 | 2/20 | 0.87 |
| ▸ | RET | P07949 | 2/20 | 0.87 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.87 |
| ▸ | PLK4 | O00444 | 1/20 | 0.87 |
| ▸ | CIT | O14578 | 1/20 | 0.87 |
| ▸ | GAK | O14976 | 1/20 | 0.87 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.87 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.87 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.87 |
| ▸ | STK10 | O94804 | 1/20 | 0.87 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.87 |
| ▸ | ABL1 | P00519 | 1/20 | 0.87 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vandetanib SCHEMBL29352879 | 0.93 | EGFR (1.00) | EGFRKDRFGFR1FLT1FLT4 | |
| Vandetanib SCHEMBL9044 | 0.93 | EGFR (1.00) | EGFRKDRFGFR1FLT1FLT4 | |
| Vandetanib SCHEMBL28224661 | 0.93 | EGFR (1.00) | EGFRKDRFGFR1FLT1FLT4 | |
| Vandetanib SCHEMBL1614458 | 0.92 | EGFR (1.00) | EGFRKDRFGFR1FLT1FLT4 | |
| Vandetanib SCHEMBL4637084 | 0.92 | EGFR (0.98) | EGFRKDRFGFR1FLT1FLT4 | |
| Vandetanib SCHEMBL1783178 | 0.91 | EGFR (0.89) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL6060759 | 0.90 | EGFR (0.86) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL10102554 | 0.90 | RET (1.00) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL29564017 | 0.90 | RET (1.00) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL13458986 | 0.90 | RET (0.82) | EGFRKDRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056839-A1 | COMBINATION APPROACHES TO CANCER TREATMENT | Auckland Uniservices Limited (NZ) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008033040-A1 | COMBINATION APPROACHES TO CANCER TREATMENT | AUCKLAND UNISERVICES LIMITED (NZ) | 2008-03-20 | — | — | WO | disclosed |