Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 18/20 | 1.00 |
| ▸ | GRM5 | P41594 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15903096 | 1.00 | SORT1 (1.00) | SORT1GRM5ALDH1A1HPGDHSD17B10 | |
| SCHEMBL15903094 | 0.95 | SORT1 (1.00) | SORT1 | |
| SCHEMBL29564231 | 0.95 | SORT1 (1.00) | SORT1 | |
| SCHEMBL20610068 | 0.86 | SORT1 (0.76) | SORT1GRM5ALDH1A1HPGDHSD17B10 | |
| SCHEMBL29981174 | 0.86 | SORT1 (0.90) | SORT1GRM5ALDH1A1HPGDHSD17B10 | |
| SCHEMBL30415774 | 0.86 | SORT1 (0.76) | SORT1GRM5ALDH1A1HPGDHSD17B10 | |
| SCHEMBL15903424 | 0.86 | SORT1 (0.90) | SORT1GRM5ALDH1A1HPGDHSD17B10 | |
| SCHEMBL15903683 | 0.84 | SORT1 (0.90) | SORT1GRM5ALDH1A1 | |
| SCHEMBL29981587 | 0.84 | SORT1 (0.90) | SORT1GRM5ALDH1A1 | |
| SCHEMBL15903313 | 0.84 | SORT1 (0.90) | SORT1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116194096-A | Sortilin antagonists for preventing and treating hearing impairment | 因苏森斯有限公司 | 2023-05-30 | — | — | CN | claimed |
| CN-115297856-A | Sortilin antagonists for the treatment of diabetic retinopathy | 舒感有限公司 | 2022-11-04 | — | — | CN | claimed |
| EP-4225280-A1 | A SORTILIN ANTAGONIST FOR USE IN THE PREVENTION OR TREATMENT OF HEARING LOSS | Insusense ApS (DK) | 2023-08-16 | — | — | EP | disclosed |
| CN-116194096-A | Sortilin antagonists for preventing and treating hearing impairment | 因苏森斯有限公司 | 2023-05-30 | — | — | CN | disclosed |
| EP-4121033-A1 | SORTILIN ANTAGONISTS FOR USE IN THE TREATMENT OF DIABETIC RETINOPATHY | Insusense ApS (DK) | 2023-01-25 | — | — | EP | disclosed |
| CN-115297856-A | Sortilin antagonists for the treatment of diabetic retinopathy | 舒感有限公司 | 2022-11-04 | — | — | CN | disclosed |
| WO-2022074119-A1 | A SORTILIN ANTAGONIST FOR USE IN THE PREVENTION OR TREATMENT OF HEARING LOSS | INSUSENSE ApS (DK) | 2022-04-14 | — | — | WO | disclosed |