Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 15/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MGLL | Q99685 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23675339 | 1.00 | HPGD (1.00) | HPGDALDH1A1MGLLTSHRHTT | |
| SCHEMBL23680811 | 0.86 | HPGD (0.76) | HPGDALDH1A1MGLL | |
| SCHEMBL23675340 | 0.80 | HPGD (1.00) | HPGDALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL23680787 | 0.79 | HPGD (1.00) | HPGDALDH1A1NPC1RAB9A | |
| SCHEMBL23680874 | 0.79 | HPGD (0.65) | HPGDALDH1A1MGLLTSHRHTT | |
| SCHEMBL3457036 | 0.76 | ALDH1A1 (0.70) | HPGDALDH1A1MGLLNPC1RAB9A | |
| SCHEMBL29944586 | 0.76 | ALDH1A1 (0.70) | HPGDALDH1A1MGLLNPC1RAB9A | |
| SCHEMBL23680788 | 0.76 | HPGD (1.00) | HPGDALDH1A1MGLLTSHRSMN1; SMN2 | |
| SCHEMBL23680699 | 0.76 | HPGD (0.61) | HPGDMGLL | |
| SCHEMBL15228754 | 0.75 | HPGD (0.60) | HPGDALDH1A1MGLLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115335043-B | PGDH inhibitors and methods of making and using the same | 迈欧伏特治疗公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-117377668-A | Inhalant formulations of PGDH inhibitors and methods of use thereof | 迈欧伏特治疗公司 | 2024-01-09 | — | — | CN | disclosed |
| EP-4228650-A1 | INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF | Epirium Bio Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-4093385-A1 | PGDH INHIBITORS AND METHODS OF MAKING AND USING | Myoforte Therapeutics Inc. (US) | 2022-11-30 | — | — | EP | disclosed |
| CN-115335043-A | PGDH inhibitors and methods of making and using | 迈欧伏特治疗公司 | 2022-11-11 | — | — | CN | disclosed |
| WO-2022082009-A1 | INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF | EPIRIUM BIO INC. (US) | 2022-04-21 | — | — | WO | disclosed |