Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 1/20 | 0.40 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 14/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 6/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | HCK | P08631 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22869317 | 1.00 | QPCT (0.40) | QPCTQPCTLHSD11B1CYP1A2METAP2 | |
| SCHEMBL24394591 | 0.81 | QPCT (0.38) | QPCTQPCTLCYP1A2METAP2MDM2 | |
| SCHEMBL29565161 | 0.81 | QPCT (0.38) | QPCTQPCTLCYP1A2METAP2MDM2 | |
| SCHEMBL23054311 | 0.79 | QPCT (0.38) | QPCTQPCTLHSD11B1CYP1A2METAP2 | |
| SCHEMBL24185998 | 0.79 | QPCT (0.43) | QPCTQPCTLHSD11B1CYP1A2METAP2 | |
| SCHEMBL30701653 | 0.78 | QPCT (0.44) | QPCTQPCTLHSD11B1CYP1A2METAP2 | |
| SCHEMBL22869325 | 0.78 | QPCT (0.44) | QPCTQPCTLHSD11B1CYP1A2METAP2 | |
| SCHEMBL24185938 | 0.78 | QPCT (0.42) | QPCTQPCTLHSD11B1CYP1A2METAP2 | |
| SCHEMBL23467386 | 0.77 | QPCT (0.36) | QPCTQPCTLHSD11B1CYP1A2METAP2 | |
| SCHEMBL24394501 | 0.77 | PLAU (0.40) | QPCTQPCTLHSD11B1CYP1A2METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4212524-A1 | CD73 INHIBITOR AND APPLICATION THEREOF IN MEDICINE | Betta Pharmaceuticals Co., Ltd (CN) | 2023-07-19 | — | — | EP | disclosed |
| CN-116348118-A | CD73 inhibitor and application thereof in medicine | 贝达药业股份有限公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-111819173-B | CD73 inhibitors | 伊莱利利公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-116134029-A | Oxo-nitrogen ring derivative regulator, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-05-16 | — | — | CN | disclosed |
| WO-2022121914-A1 | OXO-NITROGEN RING DERIVATIVE REGULATOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 上海翰森生物医药科技有限公司 | 2022-06-16 | — | — | WO | disclosed |
| CN-114502548-A | Crystalline forms of a CD73 inhibitor | 伊莱利利公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2022090711-A1 | COMPOUNDS AS CD73 INHIBITORS | AdoRx Therapeutics Limited (GB) | 2022-05-05 | — | — | WO | disclosed |