Sugi Predict

Sugi Predict / Compounds / SCHEMBL29566497

SCHEMBL29566497

SCHEMBL29566497

C[Si](C)(C)C#Cc1ncc(Cl)cc1N1CCOCC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 2/20 0.38
▸ MAPT P10636 3/20 0.37
▸ TDP1 Q9NUW8 1/20 0.37
▸ GAA P10253 2/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ ALDH1A1 P00352 1/20 0.36
▸ CNR2 P34972 3/20 0.36
▸ THRB P10828 2/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ NCF1 P14598 1/20 0.35
▸ RAF1 P04049 1/20 0.35
▸ ALOX15 P16050 1/20 0.35
▸ TSHR P16473 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ LMNA P02545 1/20 0.35
▸ TP53 P04637 1/20 0.35
▸ ALDH3A1 P30838 1/20 0.35
▸ ALDH1A3 P47895 1/20 0.35
▸ ADK P55263 1/20 0.34
▸ PRKDC P78527 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24312157 1.00 MAPK1 (0.38) MAPK1MAPTTDP1GAASMN1; SMN2
SCHEMBL24312228 0.87 RAF1 (0.43) MAPK1MAPTTDP1GAASMN1; SMN2
SCHEMBL30378778 0.83 CCR5 (0.39) MAPK1MAPTSMN1; SMN2ALDH1A1KDM4E
SCHEMBL26087675 0.83 CCR5 (0.39) MAPK1MAPTSMN1; SMN2ALDH1A1KDM4E
SCHEMBL29567366 0.82 MAP3K14 (0.41) MAPK1MAPTTDP1GAASMN1; SMN2
SCHEMBL24312573 0.82 MAP3K14 (0.41) MAPK1MAPTTDP1GAASMN1; SMN2
SCHEMBL24312591 0.82 RAF1 (0.38) MAPK1MAPTTDP1GAASMN1; SMN2
SCHEMBL29566145 0.82 RAF1 (0.38) MAPK1MAPTTDP1GAASMN1; SMN2
SCHEMBL24312146 0.82 RAF1 (0.38) MAPK1MAPTTDP1GAASMN1; SMN2
SCHEMBL29610451 0.82 RAF1 (0.38) MAPK1MAPTTDP1GAASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11746095-B2 Inhibtors of RAF kinases KINNATE BIOPHARMA INC. (US) 2023-09-05 — — US disclosed
WO-2023070053-A1 INHIBITORS OF RAF KINASES KINNATE BIOPHARMA INC. (US) 2023-04-27 — — WO disclosed
US-20220356160-A1 INHIBITORS OF RAF KINASES Pierre Fabre Médicament (FR) 2022-11-10 — — US disclosed
US-11377431-B2 Inhibitors of RAF kinases KINNATE BIOPHARMA INC. (US) 2022-07-05 — — US disclosed
US-20220112170-A1 INHIBITORS OF RAF KINASES Pierre Fabre Médicament (FR) 2022-04-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220112170-A1 INHIBITORS OF RAF KINASES BRAF, RAF1, ARAF MAPK1 268/4885MAPT 2859/4885TDP1 1712/4885
US-11746095-B2 Inhibtors of RAF kinases RAF1, BRAF, ARAF MAPK1 673/4885MAPT 3440/4885TDP1 2312/4885
US-20220356160-A1 INHIBITORS OF RAF KINASES BRAF, RAF1, ARAF MAPK1 268/4885MAPT 2859/4885TDP1 1712/4885
US-11377431-B2 Inhibitors of RAF kinases BRAF, RAF1, ARAF MAPK1 268/4885MAPT 2859/4885TDP1 1712/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.