Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 2/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.41 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310082 | 1.00 | ALPL (0.42) | ALPLPGRKEAP1NFE2L2PGAM1 | |
| SCHEMBL29566388 | 0.91 | TDP1 (0.42) | TSHRSMN1; SMN2TDP1ALDH1A1LMNA | |
| SCHEMBL24310230 | 0.91 | TDP1 (0.42) | TSHRSMN1; SMN2TDP1ALDH1A1LMNA | |
| SCHEMBL29566852 | 0.91 | TDP1 (0.44) | PGRTSHRSMN1; SMN2TDP1FFAR4 | |
| SCHEMBL24310180 | 0.91 | TDP1 (0.44) | PGRTSHRSMN1; SMN2TDP1FFAR4 | |
| SCHEMBL26806777 | 0.90 | TDP1 (0.40) | KAT6ATSHRSMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL24309354 | 0.90 | TDP1 (0.45) | TSHRSMN1; SMN2TDP1SLC40A1ALDH1A1 | |
| SCHEMBL29567008 | 0.90 | TDP1 (0.45) | TSHRSMN1; SMN2TDP1SLC40A1ALDH1A1 | |
| SCHEMBL24310800 | 0.89 | TDP1 (0.42) | KAT6ATSHRSMN1; SMN2TDP1SLC40A1 | |
| SCHEMBL29567109 | 0.89 | TDP1 (0.42) | KAT6ATSHRSMN1; SMN2TDP1SLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |