Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KIF18A | Q8NI77 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 3/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.34 |
| ▸ | GPR39 | O43194 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310192 | 1.00 | MAPK1 (0.39) | MAPK1TDP1MAPTKIF18AALDH1A1 | |
| SCHEMBL24310196 | 0.81 | TDP1 (0.40) | MAPK1TDP1MAPTALDH1A1HRH1 | |
| SCHEMBL29566739 | 0.79 | MAPK1 (0.48) | MAPK1TDP1MAPTALDH1A1GPR39 | |
| SCHEMBL24310193 | 0.79 | MAPK1 (0.48) | MAPK1TDP1MAPTALDH1A1GPR39 | |
| SCHEMBL26812723 | 0.77 | MAPT (0.50) | MAPK1TDP1MAPTALDH1A1GPR39 | |
| SCHEMBL26812951 | 0.76 | MAPK1 (0.47) | MAPK1TDP1MAPTALDH1A1GPR39 | |
| SCHEMBL26812838 | 0.76 | MAPK1 (0.46) | MAPK1TDP1MAPTALDH1A1GPR39 | |
| SCHEMBL26813002 | 0.75 | GPR39 (0.53) | MAPK1TDP1MAPTALDH1A1GPR39 | |
| SCHEMBL26806813 | 0.73 | MAPT (0.61) | MAPK1TDP1MAPTALDH1A1GPR39 | |
| SCHEMBL26812825 | 0.72 | TDP1 (0.51) | MAPK1TDP1MAPTALDH1A1GPR39 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |