Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.40 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309642 | 1.00 | POLB (0.43) | POLBSMN1; SMN2TSHRMAPTPIK3C2B | |
| SCHEMBL24309603 | 0.90 | POLB (0.45) | POLBSMN1; SMN2TSHRMAPTPIK3C2B | |
| SCHEMBL29566936 | 0.90 | SMN1; SMN2 (0.40) | POLBSMN1; SMN2TSHRMAPTPIK3C2B | |
| SCHEMBL24310351 | 0.90 | SMN1; SMN2 (0.40) | POLBSMN1; SMN2TSHRMAPTPIK3C2B | |
| SCHEMBL26807167 | 0.89 | MAPT (0.45) | POLBSMN1; SMN2TSHRMAPTPIK3C2B | |
| SCHEMBL24310577 | 0.86 | SMN1; SMN2 (0.40) | POLBSMN1; SMN2TSHRMAPTPIK3C2B | |
| SCHEMBL29566688 | 0.86 | SMN1; SMN2 (0.40) | POLBSMN1; SMN2TSHRMAPTPIK3C2B | |
| SCHEMBL26807163 | 0.86 | SMN1; SMN2 (0.40) | POLBSMN1; SMN2TSHRMAPTPIK3C2B | |
| SCHEMBL29567277 | 0.85 | PGR (0.42) | POLBSMN1; SMN2TSHRMAPTPKM | |
| SCHEMBL26807133 | 0.85 | PGR (0.42) | POLBSMN1; SMN2TSHRMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |