Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310039 | 1.00 | GFER (0.39) | GFEREGFRFGFR1KDRAURKA | |
| SCHEMBL26810272 | 0.91 | EGFR (0.38) | EGFRFGFR1KDRAURKAAURKB | |
| SCHEMBL29566612 | 0.91 | TSHR (0.43) | EGFRFGFR1KDRTSHRSMN1; SMN2 | |
| SCHEMBL24310345 | 0.91 | TSHR (0.43) | EGFRFGFR1KDRTSHRSMN1; SMN2 | |
| SCHEMBL29567535 | 0.90 | EGFR (0.38) | EGFRFGFR1KDRAURKAAURKB | |
| SCHEMBL24310791 | 0.90 | EGFR (0.38) | EGFRFGFR1KDRAURKAAURKB | |
| SCHEMBL26810270 | 0.90 | AURKA (0.37) | EGFRFGFR1KDRAURKAAURKB | |
| SCHEMBL24309560 | 0.90 | F2 (0.38) | EGFRFGFR1KDRTSHRSMN1; SMN2 | |
| SCHEMBL29566776 | 0.90 | F2 (0.38) | EGFRFGFR1KDRTSHRSMN1; SMN2 | |
| SCHEMBL24310099 | 0.90 | BRD4 (0.38) | EGFRFGFR1KDRTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |