Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310791 | 1.00 | EGFR (0.38) | EGFRFGFR1KDRENPP2ACLY | |
| SCHEMBL29566644 | 0.92 | FGFR1 (0.39) | EGFRFGFR1KDRGPR119AURKA | |
| SCHEMBL26874925 | 0.92 | FGFR1 (0.39) | EGFRFGFR1KDRGPR119AURKA | |
| SCHEMBL26810134 | 0.91 | PTGDR2 (0.41) | EGFRFGFR1KDRGPR119CYP3A4 | |
| SCHEMBL29566838 | 0.90 | GFER (0.39) | EGFRFGFR1KDRTSHRSMN1; SMN2 | |
| SCHEMBL24310039 | 0.90 | GFER (0.39) | EGFRFGFR1KDRTSHRSMN1; SMN2 | |
| SCHEMBL26810141 | 0.90 | GPR119 (0.38) | EGFRFGFR1KDRGPR119AURKA | |
| SCHEMBL26810137 | 0.89 | NR1H2 (0.39) | EGFRFGFR1KDRGPR119CCR2 | |
| SCHEMBL26810139 | 0.89 | CCR2 (0.37) | EGFRFGFR1KDRGPR119CCR2 | |
| SCHEMBL26810132 | 0.89 | EGFR (0.36) | EGFRFGFR1KDRGPR119CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |