Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 7/20 | 0.37 |
| ▸ | JAK2 | O60674 | 4/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | BRD2 | P25440 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.35 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.35 |
| ▸ | BUB1B | O60566 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310157 | 1.00 | RAD52 (0.38) | RAD52BRD4JAK2FLT3MAP4K1 | |
| SCHEMBL24310167 | 0.94 | RAD52 (0.37) | RAD52BRD4JAK2FLT3MAP4K1 | |
| SCHEMBL29566354 | 0.94 | RAD52 (0.37) | RAD52BRD4JAK2FLT3MAP4K1 | |
| SCHEMBL29566980 | 0.92 | HTR1A (0.40) | RAD52BRD4JAK2FLT3JAK1 | |
| SCHEMBL24310151 | 0.92 | HTR1A (0.40) | RAD52BRD4JAK2FLT3JAK1 | |
| SCHEMBL24310187 | 0.92 | RAD52 (0.36) | RAD52BRD4JAK2FLT3MAP4K1 | |
| SCHEMBL29566963 | 0.92 | RAD52 (0.36) | RAD52BRD4JAK2FLT3MAP4K1 | |
| SCHEMBL29567094 | 0.90 | HTR1A (0.38) | BRD4ALDH1A1HPGDHTR1AHTR7 | |
| SCHEMBL26812633 | 0.90 | HTR1A (0.38) | BRD4ALDH1A1HPGDHTR1AHTR7 | |
| SCHEMBL24310422 | 0.89 | PDE2A (0.40) | RAD52BRD4JAK2MAP4K1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |