Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.36 |
| ▸ | HTR7 | P34969 | 7/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | HTR1F | P30939 | 1/20 | 0.32 |
| ▸ | PCK1 | P35558 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 3/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | INSR | P06213 | 1/20 | 0.30 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310107 | 1.00 | HTR1A (0.36) | HTR1AHTR7SCN9ADRD2HTR6 | |
| SCHEMBL24310541 | 0.89 | SCN9A (0.36) | HTR1AHTR7SCN9AHTR6PCK1 | |
| SCHEMBL29566894 | 0.89 | SCN9A (0.36) | HTR1AHTR7SCN9AHTR6PCK1 | |
| SCHEMBL29566773 | 0.88 | SCN9A (0.34) | HTR1AHTR7SCN9AHTR6HTR1F | |
| SCHEMBL24309558 | 0.88 | SCN9A (0.34) | HTR1AHTR7SCN9AHTR6HTR1F | |
| SCHEMBL24309559 | 0.88 | SCN9A (0.36) | HTR1AHTR7SCN9APCK1PTK2 | |
| SCHEMBL29567274 | 0.88 | SCN9A (0.36) | HTR1AHTR7SCN9APCK1PTK2 | |
| SCHEMBL24310731 | 0.88 | HTR1A (0.37) | HTR1AHTR7SCN9ADRD2HTR6 | |
| SCHEMBL24310520 | 0.88 | HTR1A (0.34) | HTR1AHTR7SCN9ADRD2HTR6 | |
| SCHEMBL29567870 | 0.88 | HTR1A (0.37) | HTR1AHTR7SCN9ADRD2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |