Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310553 | 1.00 | FGFR1 (0.38) | FGFR1EGFRKDRBRD4CREBBP | |
| SCHEMBL26810170 | 0.93 | EGFR (0.38) | FGFR1EGFRKDRBRD4CREBBP | |
| SCHEMBL26810181 | 0.92 | BRD4 (0.39) | FGFR1EGFRKDRBRD4 | |
| SCHEMBL29566567 | 0.92 | BRD4 (0.38) | FGFR1EGFRKDRBRD4PTK2 | |
| SCHEMBL24310099 | 0.92 | BRD4 (0.38) | FGFR1EGFRKDRBRD4PTK2 | |
| SCHEMBL26810183 | 0.91 | CCR2 (0.37) | FGFR1EGFRKDRBRD4IGF1R | |
| SCHEMBL26810272 | 0.90 | EGFR (0.38) | FGFR1EGFRKDRCREBBPTP53 | |
| SCHEMBL29566721 | 0.90 | PTK2 (0.39) | FGFR1EGFRKDRBRD4PTK2 | |
| SCHEMBL26810180 | 0.90 | BRD4 (0.37) | FGFR1EGFRKDRBRD4TP53 | |
| SCHEMBL26812018 | 0.90 | PTK2 (0.39) | FGFR1EGFRKDRBRD4PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |