Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.37 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309374 | 1.00 | POLB (0.39) | POLBSMN1; SMN2PIK3C2BPIK3C2GTSHR | |
| SCHEMBL29566908 | 0.94 | POLB (0.37) | POLBSMN1; SMN2PIK3C2BPIK3C2GTSHR | |
| SCHEMBL24310682 | 0.94 | POLB (0.37) | POLBSMN1; SMN2PIK3C2BPIK3C2GTSHR | |
| SCHEMBL26811511 | 0.86 | POLB (0.40) | POLBSMN1; SMN2PIK3C2BPIK3C2GTSHR | |
| SCHEMBL29567299 | 0.85 | POLB (0.42) | POLBSMN1; SMN2TSHRSCN9APRMT1 | |
| SCHEMBL24309373 | 0.85 | POLB (0.42) | POLBSMN1; SMN2TSHRSCN9APRMT1 | |
| SCHEMBL29567242 | 0.83 | POLB (0.41) | POLBPIK3C2BPIK3C2GTSHRPRMT1 | |
| SCHEMBL26651221 | 0.83 | POLB (0.41) | POLBPIK3C2BPIK3C2GTSHRPRMT1 | |
| SCHEMBL24309376 | 0.81 | HTR1A (0.41) | SMN1; SMN2TSHRSCN9AHTR6 | |
| SCHEMBL29566724 | 0.81 | HTR1A (0.41) | SMN1; SMN2TSHRSCN9AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |