Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 7/20 | 0.74 |
| ▸ | RXRA | P19793 | 4/20 | 0.60 |
| ▸ | RXRB | P28702 | 4/20 | 0.60 |
| ▸ | RXRG | P48443 | 4/20 | 0.60 |
| ▸ | RARB | P10826 | 1/20 | 0.60 |
| ▸ | RARG | P13631 | 1/20 | 0.60 |
| ▸ | CYP26B1 | Q9NR63 | 7/20 | 0.46 |
| ▸ | PPARG | P37231 | 4/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16516849 | 1.00 | CYP26A1 (0.74) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL17911577 | 0.90 | CYP26A1 (0.60) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL22838062 | 0.85 | CYP26A1 (0.55) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL17911573 | 0.85 | CYP26A1 (1.00) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL8102850 | 0.85 | RXRA (0.55) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL17911584 | 0.84 | CYP26A1 (0.67) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL29567511 | 0.84 | CYP26A1 (0.67) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL22838036 | 0.83 | CYP26A1 (0.52) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL30174998 | 0.83 | CYP26A1 (0.63) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL17911578 | 0.79 | CYP26B1 (0.65) | CYP26A1RXRARXRBRXRGCYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044216-B1 | NOVEL AND SPECIFIC INHIBITORS OF CYTOCHROME P450 26 RETINOIC ACID HYDROXYLASE | UNIV WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2022-02-23 | — | — | EP | claimed |
| EP-4083029-A1 | NOVEL AND SPECIFIC INHIBITORS OF CYTOCHROME P450 26 RETINOIC ACID HYDROXYLASE | University of Washington through its Center for Commercialization (US) | 2022-11-02 | — | — | EP | disclosed |
| EP-3044216-B1 | NOVEL AND SPECIFIC INHIBITORS OF CYTOCHROME P450 26 RETINOIC ACID HYDROXYLASE | UNIV WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2022-02-23 | — | — | EP | disclosed |