Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PGR | P06401 | 3/20 | 0.44 |
| ▸ | GPR39 | O43194 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310003 | 1.00 | SMN1; SMN2 (0.57) | SMN1; SMN2TSHRPKMGAAKDM4E | |
| SCHEMBL26807086 | 0.92 | TSHR (0.49) | SMN1; SMN2TSHRPKMGAAKDM4E | |
| SCHEMBL24309985 | 0.92 | TSHR (0.56) | SMN1; SMN2TSHRPKMGAAKDM4E | |
| SCHEMBL26811103 | 0.90 | TSHR (0.60) | SMN1; SMN2TSHRPKMGAAKDM4E | |
| SCHEMBL26810957 | 0.88 | TSHR (0.54) | SMN1; SMN2TSHRPKMGAAKDM4E | |
| SCHEMBL26807087 | 0.87 | PKM (0.50) | SMN1; SMN2TSHRPKMKDM4EALDH1A1 | |
| SCHEMBL24298133 | 0.86 | SMN1; SMN2 (0.45) | SMN1; SMN2TSHRPKMALDH1A1LMNA | |
| SCHEMBL29457761 | 0.86 | SMN1; SMN2 (0.45) | SMN1; SMN2TSHRPKMALDH1A1LMNA | |
| SCHEMBL24310345 | 0.86 | TSHR (0.43) | SMN1; SMN2TSHRPKMGAAKDM4E | |
| SCHEMBL29566612 | 0.86 | TSHR (0.43) | SMN1; SMN2TSHRPKMGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |