Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ono-8539. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 2/20 | 0.32 |
| ▸ | RXRB | P28702 | 2/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ono-8539 SCHEMBL214853 | 1.00 | MCL1 (0.33) | MCL1TRPM8EP300NLRP3KDM5A | |
| SCHEMBL15456470 | 0.92 | NLRP3 (0.34) | EP300NLRP3NPC1RAB9A | |
| SCHEMBL215320 | 0.90 | MCL1 (0.36) | MCL1EP300KDM5AKDM4CKDM5B | |
| SCHEMBL213550 | 0.90 | NLRP3 (0.34) | TRPM8NLRP3KDM5AKDM4CKDM5B | |
| SCHEMBL214578 | 0.90 | MCL1 (0.35) | MCL1EP300KDM5AKDM4CKDM5B | |
| SCHEMBL215919 | 0.89 | RXRB (0.44) | TRPM8EP300RXRARXRBNPC1 | |
| SCHEMBL213408 | 0.88 | MCL1 (0.34) | MCL1TRPM8RXRARXRBMRGPRX4 | |
| SCHEMBL214486 | 0.87 | RECQL (0.35) | EP300RAB9A | |
| SCHEMBL214485 | 0.87 | RECQL (0.35) | EP300RAB9A | |
| SCHEMBL212682 | 0.84 | MCL1 (0.35) | MCL1RXRARXRBMRGPRX4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3686188-B1 | PYRAZOLE DERIVATIVE, OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | KISSEI PHARMACEUTICAL (JP) | 2022-04-06 | — | — | EP | disclosed |