Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 13/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22717805 | 1.00 | KMT2A (0.39) | KMT2AGPBAR1KDM4CKDM4EMEN1 | |
| SCHEMBL22717701 | 0.87 | L3MBTL1 (0.44) | KMT2AGPBAR1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL25153545 | 0.85 | GPBAR1 (0.50) | GPBAR1KDM4C | |
| SCHEMBL31019033 | 0.85 | GPBAR1 (0.50) | GPBAR1KDM4C | |
| SCHEMBL29574048 | 0.82 | KDM4C (0.42) | KMT2AGPBAR1KDM4CKDM4EMEN1 | |
| SCHEMBL22717553 | 0.82 | KDM4C (0.42) | KMT2AGPBAR1KDM4CKDM4EMEN1 | |
| SCHEMBL29695033 | 0.80 | POLQ (0.50) | KMT2ATAS2R14POLB | |
| SCHEMBL24501117 | 0.80 | POLQ (0.50) | KMT2ATAS2R14POLB | |
| SCHEMBL31083513 | 0.79 | ALB (0.44) | KMT2AKDM4CKDM4EMEN1KDM6B | |
| SCHEMBL22718078 | 0.77 | EIF4EBP1 (0.41) | KMT2AALDH1A1TAS2R14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976608-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |