Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25308804 | 0.77 | PARP1 (0.46) | KMT2APRKCQDDB1CRBNPARP1 | |
| SCHEMBL30572109 | 0.75 | KMT2A (0.42) | KMT2APARP1HSD11B1MEN1CYP1A2 | |
| SCHEMBL12142200 | 0.74 | KMT2A (0.48) | KMT2APRKCQPARP1HSD11B1MEN1 | |
| SCHEMBL883905 | 0.71 | KMT2A (0.58) | KMT2APARP1MEN1CYP1A2CYP3A4 | |
| SCHEMBL28275410 | 0.71 | CHIA (0.65) | KMT2APRKCQPARP1MEN1CYP1A2 | |
| SCHEMBL30945091 | 0.71 | EPHX2 (0.52) | KMT2APRKCQMEN1CYP1A2CYP3A4 | |
| SCHEMBL4538970 | 0.71 | EPHX2 (0.52) | KMT2APRKCQMEN1CYP1A2CYP3A4 | |
| SCHEMBL29421198 | 0.70 | KMT2A (0.52) | KMT2AMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL29835066 | 0.70 | KMT2A (0.52) | KMT2AMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL29173062 | 0.70 | KMT2A (0.52) | KMT2AMEN1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976608-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |