Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | PRKCH | P24723 | 1/20 | 0.39 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4538970 | 0.83 | EPHX2 (0.52) | KMT2ATRPV1MEN1CYP1A2CYP3A4 | |
| SCHEMBL30945091 | 0.83 | EPHX2 (0.52) | KMT2ATRPV1MEN1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL5901187 | 0.82 | EPHX2 (0.51) | KMT2ATRPV1MEN1CYP1A2CYP3A4 | |
| SCHEMBL14377416 | 0.80 | GRIN2D (0.55) | KMT2APIK3CAMTORGRIA1MEN1 | |
| SCHEMBL883905 | 0.78 | KMT2A (0.58) | PARP1KMT2ATRPV1MEN1CYP1A2 | |
| SCHEMBL10094631 | 0.77 | HSD11B1 (0.46) | KMT2APIK3CAMTORTRPV1GRIA1 | |
| SCHEMBL29574686 | 0.77 | KMT2A (0.44) | PARP1KMT2ATRPV1DDB1CRBN | |
| SCHEMBL28189129 | 0.77 | KMT2A (0.60) | PARP1KMT2ATRPV1MEN1CYP1A2 | |
| SCHEMBL353774 | 0.74 | AURKA (0.60) | PARP1KMT2ATRPV1MEN1CYP1A2 | |
| SCHEMBL28275410 | 0.74 | CHIA (0.65) | PARP1KMT2AMEN1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023134708-A1 | THIAZOLOPYRIDYL AMIDE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | BEIGENE , LTD. (KY) | 2023-07-20 | — | — | WO | disclosed |