Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.34 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.34 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 4/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SCN4A | P35499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22550617 | 1.00 | NR1H2 (0.36) | NR1H2SMARCA2SMARCA4PBRM1NPSR1 | |
| SCHEMBL22529749 | 0.84 | TRPC6 (0.32) | — | |
| SCHEMBL30426810 | 0.80 | SMARCA2 (0.39) | NR1H2SMARCA2SMARCA4PBRM1GRM5 | |
| SCHEMBL31105081 | 0.80 | SMARCA2 (0.39) | NR1H2SMARCA2SMARCA4PBRM1GRM5 | |
| SCHEMBL31105132 | 0.80 | SMARCA2 (0.39) | NR1H2SMARCA2SMARCA4PBRM1GRM5 | |
| SCHEMBL31104864 | 0.80 | SMARCA2 (0.39) | NR1H2SMARCA2SMARCA4PBRM1GRM5 | |
| SCHEMBL30426870 | 0.80 | SMARCA2 (0.39) | NR1H2SMARCA2SMARCA4PBRM1GRM5 | |
| SCHEMBL30427091 | 0.80 | SMARCA2 (0.39) | NR1H2SMARCA2SMARCA4PBRM1GRM5 | |
| SCHEMBL22550615 | 0.79 | NPSR1 (0.34) | NR1H2SMARCA2SMARCA4PBRM1NPSR1 | |
| SCHEMBL21045788 | 0.78 | GRM1 (0.52) | GRM5GRM1TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12156874-B2 | Inhibitors of TRPC6 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2024-12-03 | — | — | US | disclosed |
| US-20220152023-A1 | INHIBITORS OF TRPC6 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220152023-A1 | INHIBITORS OF TRPC6 | TRPC6, TRPC1, TRPC3 | NR1H2 229/4885SMARCA2 3868/4885SMARCA4 3531/4885 |
| US-12156874-B2 | Inhibitors of TRPC6 | TRPC6, TRPC1, TRPC3 | NR1H2 229/4885SMARCA2 3868/4885SMARCA4 3531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.