Zatebradine

Zatebradine

SCHEMBL295751

COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HCN4 Q9Y3Q4 5/20 1.00
MAPT P10636 1/20 1.00
CYP3A4 P08684 2/20 0.98
ALOX15 P16050 1/20 0.98
DRD3 P35462 2/20 0.64
KCNH2 Q12809 2/20 0.64
CHRM2 P08172 1/20 0.64
HTR1A P08908 1/20 0.64
SLC6A4 P31645 1/20 0.64
SMPD1 P17405 6/20 0.56
CYP1A2 P05177 1/20 0.54
CYP2D6 P10635 1/20 0.54
ABCB1 P08183 2/20 0.53
BLM P54132 1/20 0.53
PMP22 Q01453 1/20 0.53
DRD2 P14416 1/20 0.49
GAA P10253 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Zatebradine SCHEMBL4242335 1.00 HCN4 (1.00) HCN4MAPTCYP3A4ALOX15DRD3
Zatebradine SCHEMBL29977754 1.00 HCN4 (1.00) HCN4MAPTCYP3A4ALOX15DRD3
Zatebradine SCHEMBL10978655 0.99 CYP3A4 (1.00) HCN4MAPTCYP3A4ALOX15DRD3
Zatebradine SCHEMBL29465193 0.99 CYP3A4 (1.00) HCN4MAPTCYP3A4ALOX15DRD3
Zatebradine SCHEMBL1588590 0.99 CYP3A4 (1.00) HCN4MAPTCYP3A4ALOX15DRD3
Zatebradine SCHEMBL1650770 0.98 HCN4 (0.96) HCN4MAPTCYP3A4ALOX15DRD3
Hydrochloric Acid SCHEMBL11094976 0.96 CYP3A4 (0.94) HCN4MAPTCYP3A4ALOX15DRD3
SCHEMBL10598399 0.96 HCN4 (0.92) HCN4MAPTCYP3A4ALOX15DRD3
SCHEMBL11088082 0.95 HCN4 (0.91) HCN4MAPTCYP3A4ALOX15DRD3
Hydrochloric Acid SCHEMBL10598067 0.95 CYP3A4 (0.92) HCN4MAPTCYP3A4ALOX15DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 711 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110073213-B Method, device and kit for determining cardiac conduction 罗斯托克大学 2024-03-29 CN claimed
US-20230270693-A1 Molecular Targets for Modulation of Dissociative and Associative States THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2023-08-31 US claimed
EP-4087469-A1 DEVICES AND METHODS FOR TREATING CANCER AND CARDIAC WASTING Nazzano Devices Limited (IE) 2022-11-16 EP claimed
US-20220347150-A1 TASIMELTEON USE IN TREATING SLEEP ABERRATIONS VANDA PHARMACEUTICALS INC. 2022-11-03 US claimed
CN-114641284-A Application of tasimelteon in treatment of abnormal sleep 万带兰制药公司 2022-06-17 CN claimed
EP-3989964-A1 TASIMELTEON USE IN TREATING SLEEP ABERRATIONS Vanda Pharmaceuticals Inc. (US) 2022-05-04 EP claimed
WO-2022035773-A1 MOLECULAR TARGETS FOR MODULATION OF DISSOCIATIVE AND ASSOCIATIVE STATES THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2022-02-17 WO claimed
EP-3810184-A2 METHODS OF TREATING OR INHIBITING ONSET OF HUNTINGTON'S DISEASE University of Rochester (US) 2021-04-28 EP claimed
CN-112654366-A Methods of treating or inhibiting the onset of huntington's disease 罗切斯特大学 2021-04-13 CN claimed
WO-2021003086-A1 TASIMELTEON USE IN TREATING SLEEP ABERRATIONS VANDA PHARMACEUTICALS INC. (US) 2021-01-07 WO claimed
EP-1276476-A2 USE OF BRADYCARDIAC SUBSTANCES IN THE TREATMENT OF MYOCARDIAL DISEASES ASSOCIATED WITH HYPERTROPHY AND NOVEL MEDICAMENT COMBINATIONS Boehringer Ingelheim Pharma KG (DE) 2003-01-22 EP claimed
WO-2002100328-A2 TREATING PAIN BY TARGETING HYPERPOLARIZATION-ACTIVATED, CYCLIC NUCLEOTIDE-GATED CHANNELS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2002-12-19 WO claimed
WO-2002100408-A2 TREATING NEUROPATHIC/INFLAMMATORY PAIN BY TARGETING A COMPOSITION (E.G. ZD7288) TO HCN PACEMAKER CHANNELS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2002-12-19 WO claimed
WO-2001078699-A2 USE OF BRADYCARDIAC SUBSTANCES IN THE TREATMENT OF MYOCARDIAL DISEASES ASSOCIATED WITH HYPERTROPHY AND NOVEL MEDICAMENT COMBINATIONS BOEHRINGER INGELHEIM PHARMA KG (DE) 2001-10-25 WO claimed
EP-0904097-A2 COMBINATIONS OF VASOPRESSIN AND ADRENERGIC AGENTS FOR THE TREATMENT OF CARDIAC ARREST Lurie, Keith G. (US) 1999-03-31 EP claimed
WO-1997036609-A2 COMBINATIONS OF VASOPRESSIN AND ADRENERGIC AGENTS FOR THE TREATMENT OF CARDIAC ARREST LURIE KEITH G (US) 1997-10-09 WO claimed
US-5643915-A ANTIINFLAMMATORY AGENTS ANDRULIS PHARMACEUTICALS CORP. (US) 1997-07-01 US claimed
US-5595987-A CARDIOVASCULAR DISORDERS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 1997-01-21 US claimed
EP-0065229-B1 BENZAZEPINES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION AS PHARMACEUTICAL PREPARATIONS Dr. Karl Thomae GmbH (DE) 1985-08-07 EP claimed
US-4490369-A HYPOTENSIVE, BRRADYCARDIAL DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1984-12-25 US claimed