Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN4 | Q9Y3Q4 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.98 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.98 |
| ▸ | DRD3 | P35462 | 2/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.64 |
| ▸ | SMPD1 | P17405 | 6/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zatebradine SCHEMBL295751 | 1.00 | HCN4 (1.00) | HCN4MAPTCYP3A4ALOX15DRD3 | |
| Zatebradine SCHEMBL4242335 | 1.00 | HCN4 (1.00) | HCN4MAPTCYP3A4ALOX15DRD3 | |
| Zatebradine SCHEMBL10978655 | 0.99 | CYP3A4 (1.00) | HCN4MAPTCYP3A4ALOX15DRD3 | |
| Zatebradine SCHEMBL29465193 | 0.99 | CYP3A4 (1.00) | HCN4MAPTCYP3A4ALOX15DRD3 | |
| Zatebradine SCHEMBL1588590 | 0.99 | CYP3A4 (1.00) | HCN4MAPTCYP3A4ALOX15DRD3 | |
| Zatebradine SCHEMBL1650770 | 0.98 | HCN4 (0.96) | HCN4MAPTCYP3A4ALOX15DRD3 | |
| Hydrochloric Acid SCHEMBL11094976 | 0.96 | CYP3A4 (0.94) | HCN4MAPTCYP3A4ALOX15DRD3 | |
| SCHEMBL10598399 | 0.96 | HCN4 (0.92) | HCN4MAPTCYP3A4ALOX15DRD3 | |
| SCHEMBL11088082 | 0.95 | HCN4 (0.91) | HCN4MAPTCYP3A4ALOX15DRD3 | |
| Hydrochloric Acid SCHEMBL10598067 | 0.95 | CYP3A4 (0.92) | HCN4MAPTCYP3A4ALOX15DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240226178-A1 | ELECTROPHYSIOLOGICAL MODIFICATION TO SUPPRESS ARRHYTHMIAS | UNIVERSITY OF WASHINGTON (US) | 2024-07-11 | — | — | US | disclosed |
| WO-2022235610-A9 | ELECTROPHYSIOLOGICAL MODIFICATION TO SUPPRESS ARRHYTHMIAS | UNIVERSITY OF WASHINGTON (US) | 2023-04-06 | — | — | WO | disclosed |
| WO-2022235610-A1 | ELECTROPHYSIOLOGICAL MODIFICATION TO SUPPRESS ARRHYTHMIAS | UNIVERSITY OF WASHINGTON (US) | 2022-11-10 | — | — | WO | disclosed |