Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 5/20 | 1.00 |
| ▸ | CDC7 | O00311 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | PRKACA | P17612 | 1/20 | 0.54 |
| ▸ | CDK7 | P50613 | 1/20 | 0.54 |
| ▸ | CDK9 | P50750 | 1/20 | 0.54 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.54 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.48 |
| ▸ | MAPK3 | P27361 | 5/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17545178 | 1.00 | ULK1 (1.00) | ULK1CDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL1917484 | 0.82 | ULK1 (0.70) | ULK1MAPK3 | |
| SCHEMBL1917489 | 0.82 | ULK1 (0.70) | ULK1MAPK3 | |
| SCHEMBL29575332 | 0.80 | ULK1 (0.66) | ULK1CDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL17547451 | 0.80 | ULK1 (0.66) | ULK1CDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL19654290 | 0.78 | ULK1 (0.64) | ULK1SYKAURKAMAPK3KDR | |
| SCHEMBL17544782 | 0.77 | ULK1 (1.00) | ULK1CDK7PTK2CDK1PTK2B | |
| SCHEMBL17547513 | 0.76 | ULK1 (1.00) | ULK1CDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL29574731 | 0.76 | ULK1 (1.00) | ULK1CDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL12998612 | 0.76 | PTK2 (0.77) | ULK1CDK7PTK2CDK1PTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3185868-B1 | NOVEL ULK1 INHIBITORS AND METHODS USING SAME | SALK INST FOR BIOLOGICAL STUDI (US) | 2022-04-06 | — | — | EP | disclosed |