SCHEMBL29576071

SCHEMBL29576071

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)O

nearest known ligand 0.80

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ GLP1R P43220 18/20 0.80
▸ GCGR P47871 9/20 0.80
▸ GIPR P48546 6/20 0.80
▸ CCKBR P32239 4/20 0.69
▸ CALCR P30988 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30460356 1.00 GLP1R (0.80) GLP1RGCGRGIPRCCKBRCALCR
SCHEMBL30645490 1.00 GLP1R (0.80) GLP1RGCGRGIPRCCKBRCALCR
SCHEMBL30473764 1.00 GLP1R (0.80) GLP1RGCGRGIPRCCKBRCALCR
SCHEMBL30205160 0.99 GLP1R (0.81) GLP1RGCGRGIPRCCKBRCALCR
SCHEMBL31099269 0.98 GLP1R (0.79) GLP1RGCGRGIPRCCKBRCALCR
SCHEMBL30473786 0.98 GLP1R (0.79) GLP1RGCGRGIPRCCKBRCALCR
SCHEMBL30473804 0.98 GLP1R (0.79) GLP1RGCGRGIPRCCKBRCALCR
SCHEMBL31072728 0.98 GLP1R (0.81) GLP1RGCGRGIPRCCKBR
Exenatide SCHEMBL20509814 0.98 GLP1R (0.81) GLP1RGCGRGIPRCCKBR
Exenatide SCHEMBL29827241 0.98 GLP1R (0.81) GLP1RGCGRGIPRCCKBR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114456276-A Preparation method and application of long-acting exenatide 中国科学院大学宁波华美医院 2022-05-10 — — CN claimed
EP-3452049-B1 GLP-1 RECEPTOR LIGAND MOIETY CONJUGATED OLIGONUCLEOTIDES AND USES THEREOF IONIS PHARMACEUTICALS INC (US) 2026-04-01 — — EP disclosed
US-20250074964-A1 STABLE GLP-1 ANALOGS FOR THE TREATMENT OF HUMAN DISEASE AND DISORDERS Ambio, Inc. 2025-03-06 — — US disclosed
US-20250051405-A1 EXTENDED RECOMBINANT POLYPEPTIDES AND COMPOSITIONS COMPRISING SAME AMUNIX PHARMACEUTICALS, INC. 2025-02-13 — — US disclosed
US-12115225-B2 GLP-1 receptor ligand moiety conjugated oligonucleotides and uses thereof ASTRAZENECA AB (SE) 2024-10-15 — — US disclosed
US-20240293563-A1 GLP-1 RECEPTOR LIGAND MOIETY CONJUGATED OLIGONUCLEOTIDES AND USES THEREOF ASTRAZENECA AB (SE) 2024-09-05 — — US disclosed
US-12071456-B2 Extended recombinant polypeptides and compositions comprising same AMUNIX PHARMACEUTICALS, INC. (US) 2024-08-27 — — US disclosed
US-20230324389-A1 COMPOSITIONS AND METHODS RELATED TO ACTIVATABLE THERAPEUTIC AGENTS AMUNIX PHARMACEUTICALS, INC. 2023-10-12 — — US disclosed
US-20230303640-A1 EXENDIN-4 PEPTIDE ANALOGS TXP PHARMA AG (CH) 2023-09-28 — — US disclosed
CN-113456820-B Compositions comprising GLP-1 receptor agonists and glucagon receptor agonists and uses thereof 派格生物医药(苏州)股份有限公司 2023-09-08 — — CN disclosed
CN-113546159-B Compositions comprising GLP-1 receptor agonists and glucagon receptor agonists and uses thereof 派格生物医药(苏州)股份有限公司 2023-09-08 — — CN disclosed
US-20230158247-A1 MEDICAMENT DELIVERY DEVICE SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2023-05-25 — — US disclosed
CN-114456276-A Preparation method and application of long-acting exenatide 中国科学院大学宁波华美医院 2022-05-10 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240293563-A1 GLP-1 RECEPTOR LIGAND MOIETY CONJUGATED OLIGONUCLEOTIDES AND USES THEREOF GLP1R, GIPR, GRPR GLP1R 1/4885GCGR 4/4885GIPR 2/4885
US-20250074964-A1 STABLE GLP-1 ANALOGS FOR THE TREATMENT OF HUMAN DISEASE AND DISORDERS GLP1R, GIPR, GPR119 GLP1R 1/4885GCGR 5/4885GIPR 2/4885
US-12115225-B2 GLP-1 receptor ligand moiety conjugated oligonucleotides and uses thereof GLP1R, GIPR, GRPR GLP1R 1/4885GCGR 4/4885GIPR 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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