Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.47 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 4/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | RORA | P35398 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | RORB | Q92753 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | DDO | Q99489 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24335125 | 1.00 | DAO (0.47) | DAOGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL11509851 | 0.86 | DAO (0.56) | DAOALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL24335157 | 0.83 | MEN1 (0.49) | DAOGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL29580107 | 0.83 | GRIA1 (0.63) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL24335260 | 0.83 | GRIA1 (0.63) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL24335140 | 0.80 | PDE5A (0.48) | GRIA1GRIA2GRIA3GRIA4RORA | |
| SCHEMBL29580737 | 0.80 | PDE5A (0.48) | GRIA1GRIA2GRIA3GRIA4RORA | |
| SCHEMBL11506775 | 0.80 | DAO (0.50) | DAOALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL29580047 | 0.80 | ALDH1A1 (0.56) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL24335150 | 0.80 | ALDH1A1 (0.56) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232438-A1 | COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | The Governors of the University of Alberta (CA) | 2023-08-30 | — | — | EP | disclosed |
| CN-116528867-A | Compounds for the treatment of Alzheimer's disease | 艾伯塔大学理事会 | 2023-08-01 | — | — | CN | disclosed |
| WO-2022082305-A1 | COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2022-04-28 | — | — | WO | disclosed |