Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | GRM1 | Q13255 | 9/20 | 0.45 |
| ▸ | GRM5 | P41594 | 8/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24330068 | 1.00 | PDK4 (0.57) | PDK4HTR6CNR1DGAT2JAK1 | |
| SCHEMBL22532889 | 0.97 | PDK4 (0.58) | PDK4HTR6CNR1DGAT2JAK1 | |
| SCHEMBL30026536 | 0.97 | PDK4 (0.58) | PDK4HTR6CNR1DGAT2JAK1 | |
| SCHEMBL24315967 | 0.82 | PDK4 (0.50) | PDK4HTR6CNR1JAK1GRM1 | |
| SCHEMBL22532732 | 0.81 | KDM4E (0.45) | PDK4 | |
| SCHEMBL19297151 | 0.80 | PDK4 (0.61) | PDK4HTR6CNR1DGAT2JAK1 | |
| SCHEMBL30074119 | 0.80 | PDK4 (0.61) | PDK4HTR6CNR1JAK1GRM1 | |
| SCHEMBL6847847 | 0.79 | PDK4 (0.69) | PDK4HTR6CNR1DGAT2JAK1 | |
| SCHEMBL19297042 | 0.79 | PDK4 (0.62) | PDK4HTR6CNR1DGAT2JAK1 | |
| SCHEMBL19284578 | 0.79 | PDK4 (0.65) | PDK4HTR6CNR1DGAT2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4228625-A1 | TRICYCLIC HETEROBIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF TARGETED PROTEINS | C4 Therapeutics, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081928-A1 | TRICYCLIC HETEROBIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF TARGETED PROTEINS | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |