Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.69 |
| ▸ | HTR6 | P50406 | 1/20 | 0.59 |
| ▸ | GRM5 | P41594 | 9/20 | 0.53 |
| ▸ | GRM1 | Q13255 | 9/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.48 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19284633 | 0.89 | PDK4 (0.61) | PDK4HTR6GRM5GRM1NAMPT | |
| SCHEMBL19284578 | 0.88 | PDK4 (0.65) | PDK4HTR6GRM5GRM1NAMPT | |
| SCHEMBL6808096 | 0.87 | PDK4 (0.59) | PDK4HTR6GRM5GRM1NAMPT | |
| SCHEMBL19297116 | 0.87 | PDK4 (0.59) | PDK4HTR6GRM5GRM1NAMPT | |
| SCHEMBL5359091 | 0.87 | PDK4 (0.59) | PDK4HTR6GRM5GRM1NAMPT | |
| SCHEMBL7953308 | 0.86 | HTR6 (0.58) | PDK4HTR6GRM5GRM1NAMPT | |
| SCHEMBL19297042 | 0.86 | PDK4 (0.62) | PDK4HTR6GRM5GRM1NAMPT | |
| SCHEMBL19284673 | 0.86 | PDK4 (0.62) | PDK4HTR6GRM5GRM1NAMPT | |
| SCHEMBL6811252 | 0.85 | PDK4 (0.57) | PDK4HTR6GRM5GRM1NAMPT | |
| SCHEMBL19297151 | 0.85 | PDK4 (0.61) | PDK4HTR6GRM5GRM1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040242609-A1 | Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof | SYNAPTIC PHARMACEUTICAL CORPORATION | 2004-12-02 | — | — | US | disclosed |
| US-20030082623-A1 | DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof | H. LUNDBECK A/S (DK) | 2003-05-01 | — | — | US | disclosed |
| US-6346622-B1 | ENANTIOMORPHS AND ISOMERS | ABBOTT LABORATORIES | 2002-02-12 | — | — | US | disclosed |
| CN-1277607-A | 2-substituted 1,2-benzisothiazole derivatives and their use as serotonin antagonists (5-HT1A, 5-HT1b and 5-HT1D) | BASF AG (DE) | 2000-12-20 | — | — | CN | disclosed |
| EP-0886636-A1 | NOVEL PIPERIDINES DERIVED FROM 1-/(PIPERAZIN-1-YL)ARYL(OXY/AMINO)CARBONYL/-4-ARYL-PIPERIDINE AS SELECTIVE 5-HT-1D.BETA. RECEPTOR ANTAGONISTS | PIERRE FABRE MEDICAMENT (FR) | 1998-12-30 | — | — | EP | disclosed |
| WO-1997028140-A1 | NOVEL PIPERIDINES DERIVED FROM 1-/(PIPERAZIN-1-YL)ARYL(OXY/AMINO)CARBONYL/-4-ARYL-PIPERIDINE AS SELECTIVE 5-HT1Db RECEPTOR ANTAGONISTS | PIERRE FABRE MEDICAMENT (FR) | 1997-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030082623-A1 | DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof | MCHR1, MCHR2, MC1R | PDK4 4379/4885HTR6 70/4885GRM5 215/4885 |
| US-20040242609-A1 | Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof | MCHR1, MCHR2, MC4R | PDK4 2737/4885HTR6 115/4885GRM5 263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.