Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 6/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24496708 | 1.00 | HDAC4 (0.49) | HDAC4HDAC7HDAC5HDAC3HDAC8 | |
| SCHEMBL29499490 | 0.82 | ATM (0.47) | — | |
| SCHEMBL6327386 | 0.82 | SMN1; SMN2 (0.39) | POLBHPGDHTTCYP2C19 | |
| SCHEMBL24496706 | 0.82 | SMN1; SMN2 (0.39) | POLBHPGDHTTCYP2C19 | |
| SCHEMBL27014131 | 0.82 | SMN1; SMN2 (0.39) | POLBHPGDHTTCYP2C19 | |
| SCHEMBL27014130 | 0.82 | SMN1; SMN2 (0.39) | POLBHPGDHTTCYP2C19 | |
| SCHEMBL6327266 | 0.80 | HPGD (0.62) | POLBHPGDHTTCYP2C19NPC1 | |
| SCHEMBL24496707 | 0.80 | KMT2A (0.41) | HPGDHTTNPC1RAB9AL3MBTL1 | |
| SCHEMBL6327261 | 0.80 | KMT2A (0.41) | HPGDHTTNPC1RAB9AL3MBTL1 | |
| SCHEMBL29586933 | 0.80 | KMT2A (0.41) | HPGDHTTNPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120048-A1 | HDAC INHIBITORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2022-06-09 | — | — | WO | disclosed |