Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.36 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.34 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 3/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24313957 | 1.00 | HSD17B10 (0.37) | HSD17B10TSHRSMN1; SMN2TP53POLB | |
| SCHEMBL24314295 | 0.87 | HSD17B10 (0.40) | HSD17B10TSHRSMN1; SMN2TP53POLB | |
| SCHEMBL29587382 | 0.87 | HSD17B10 (0.40) | HSD17B10TSHRSMN1; SMN2TP53POLB | |
| SCHEMBL29588270 | 0.85 | HSD17B10 (0.39) | HSD17B10TSHRSMN1; SMN2TP53POLB | |
| SCHEMBL29587778 | 0.84 | HSD17B10 (0.39) | HSD17B10TSHRSMN1; SMN2TP53POLB | |
| SCHEMBL24314312 | 0.84 | HSD17B10 (0.39) | HSD17B10TSHRSMN1; SMN2TP53POLB | |
| SCHEMBL24313958 | 0.82 | PDE4D (0.33) | HSD17B10TSHRSMN1; SMN2PDE4DMAT2A | |
| SCHEMBL24314201 | 0.81 | PTGER4 (0.39) | TSHRSMN1; SMN2TP53PTGER4ALDH1A1 | |
| SCHEMBL24313769 | 0.80 | PTGER4 (0.38) | POLBPTGER4PDE4DALDH1A1GAA | |
| SCHEMBL29588225 | 0.80 | PTGER4 (0.38) | POLBPTGER4PDE4DALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229045-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute Inc. (US) | 2023-08-23 | — | — | EP | claimed |
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | claimed |
| EP-4229045-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |