Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24314312 | 1.00 | HSD17B10 (0.39) | HSD17B10SMN1; SMN2POLBTP53TSHR | |
| SCHEMBL29587382 | 0.88 | HSD17B10 (0.40) | HSD17B10SMN1; SMN2POLBTP53TSHR | |
| SCHEMBL24314295 | 0.88 | HSD17B10 (0.40) | HSD17B10SMN1; SMN2POLBTP53TSHR | |
| SCHEMBL29588270 | 0.86 | HSD17B10 (0.39) | HSD17B10SMN1; SMN2POLBTP53TSHR | |
| SCHEMBL24313957 | 0.84 | HSD17B10 (0.37) | HSD17B10SMN1; SMN2POLBTP53TSHR | |
| SCHEMBL29587405 | 0.84 | HSD17B10 (0.37) | HSD17B10SMN1; SMN2POLBTP53TSHR | |
| SCHEMBL24314314 | 0.81 | ALDH1A1 (0.33) | HSD17B10SMN1; SMN2POLBTP53TSHR | |
| SCHEMBL29587615 | 0.80 | PTGER4 (0.37) | POLBALDH1A1KDM4EHPGD | |
| SCHEMBL24314242 | 0.80 | PTGER4 (0.37) | POLBALDH1A1KDM4EHPGD | |
| SCHEMBL22588218 | 0.79 | POLB (0.39) | HSD17B10SMN1; SMN2POLBTP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229045-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute Inc. (US) | 2023-08-23 | — | — | EP | claimed |
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | claimed |
| EP-4229045-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |