Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAF1 | P21675 | 1/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18617405 | 1.00 | TAF1 (0.46) | TAF1TNIKHDAC8HDAC6MAPT | |
| SCHEMBL18587789 | 0.86 | CTSS (0.43) | MAPTKDM4E | |
| SCHEMBL18587305 | 0.85 | ERN1 (0.47) | MAPT | |
| SCHEMBL18586735 | 0.82 | ERN1 (0.47) | TAF1PDK2BRD4CREBBP | |
| SCHEMBL29588054 | 0.82 | ERN1 (0.47) | TAF1PDK2BRD4CREBBP | |
| Phenol SCHEMBL18587050 | 0.81 | DHODH (0.41) | — | |
| SCHEMBL28022359 | 0.76 | KAT6A (0.60) | TAF1HDAC8HDAC6DGAT2NR4A2 | |
| SCHEMBL20787390 | 0.75 | S1PR3 (0.59) | HDAC8HDAC6S1PR3 | |
| SCHEMBL28253118 | 0.75 | S1PR3 (0.46) | HDAC8HDAC6MAPTS1PR3KDM4E | |
| SCHEMBL16574196 | 0.75 | S1PR4 (0.54) | TAF1HDAC8HDAC6NUDT1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352330-B2 | Phenoxymethyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2022-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352330-B2 | Phenoxymethyl derivatives | CNKSR1, RB1, RCOR1 | TAF1 2191/4885TNIK 4055/4885HDAC8 624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.