Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.50 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18618141 | 1.00 | HPGD (0.54) | HPGDTNKS2GPR52TP53KMT2A | |
| SCHEMBL18617224 | 0.89 | SMN1; SMN2 (0.44) | HPGDTNKS2KMT2AMEN1KDM4E | |
| SCHEMBL18618089 | 0.88 | POLB (0.50) | HPGDGPR52KMT2AMEN1SMYD2 | |
| SCHEMBL22579135 | 0.86 | SMN1; SMN2 (0.59) | HPGDMRGPRX4SMYD2GAAMAPT | |
| SCHEMBL20056615 | 0.82 | HPGD (0.58) | HPGDTNKS2GPR52TP53MRGPRX4 | |
| SCHEMBL18618319 | 0.82 | MAPK1 (0.46) | HPGDTP53KDM4EMAPK1GAA | |
| SCHEMBL18617225 | 0.81 | ERN1 (0.51) | KMT2AMEN1MAPTCA2ERN1 | |
| SCHEMBL22579136 | 0.79 | HPGD (0.47) | HPGDTP53KMT2AMEN1LMNA | |
| SCHEMBL15959008 | 0.77 | HPGD (0.55) | HPGDKMT2AMEN1KDM4EMAPK1 | |
| SCHEMBL18618116 | 0.77 | NR1H4 (0.59) | HPGDKMT2AMEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352330-B2 | Phenoxymethyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2022-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352330-B2 | Phenoxymethyl derivatives | CNKSR1, RB1, RCOR1 | HPGD 2706/4885TNKS2 1409/4885GPR52 1896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.