Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | ERN1 | O75460 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | LIPC | P11150 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18618141 | 0.82 | HPGD (0.54) | HPGDCA2ERN1KDM4EMAPK1 | |
| SCHEMBL29588955 | 0.82 | HPGD (0.54) | HPGDCA2ERN1KDM4EMAPK1 | |
| SCHEMBL15959008 | 0.80 | HPGD (0.55) | HPGDKDM4EMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL16076888 | 0.80 | HSD17B1 (0.54) | ERN1HSD17B1HSD17B2 | |
| SCHEMBL12674867 | 0.78 | ERN1 (0.71) | ERN1 | |
| SCHEMBL27318299 | 0.77 | HPGD (0.51) | HPGDKDM4EMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1926950 | 0.76 | ERN1 (0.62) | HPGDERN1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11092140 | 0.75 | HPGD (0.65) | HPGDCA2ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL23471363 | 0.74 | HPGD (0.60) | HPGDALDH1A1SMN1; SMN2TP53GAA | |
| SCHEMBL12867 | 0.74 | NPC1 (0.64) | HPGDALDH1A1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970353-B1 | MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS | VERTEX PHARMA (US) | 2018-04-18 | — | — | EP | disclosed |