Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 8/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | NME2 | P22392 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29589967 | 0.91 | KDR (0.57) | KDRRAB9ANPC1MEN1KMT2A | |
| SCHEMBL29589238 | 0.91 | KDR (0.59) | KDRRAB9ANPC1MEN1KMT2A | |
| SCHEMBL29589513 | 0.89 | KDR (0.63) | KDRRAB9ANPC1MEN1KMT2A | |
| SCHEMBL29590363 | 0.87 | KDR (0.58) | KDRRAB9ANPC1MEN1KMT2A | |
| SCHEMBL29589211 | 0.84 | MEN1 (0.57) | KDRRAB9ANPC1MEN1KMT2A | |
| SCHEMBL29589683 | 0.84 | MAPT (0.51) | RAB9ANPC1ALOX5MAPTTHRB | |
| SCHEMBL29589685 | 0.83 | KDR (0.55) | KDRRAB9ANPC1MEN1KMT2A | |
| SCHEMBL29589173 | 0.81 | KDR (0.89) | KDRRAB9ANPC1MEN1KMT2A | |
| SCHEMBL28882543 | 0.81 | KDR (0.67) | KDRRAB9ANPC1MEN1KMT2A | |
| SCHEMBL29589166 | 0.76 | GRM1 (0.49) | RAB9ANPC1ALOX5MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114478549-A | Pyrazolo [3,4-d ] pyrrolo [1,2-a ] pyrimidone arylene derivative and application thereof | 中国科学院新疆理化技术研究所 | 2022-05-13 | — | — | CN | claimed |
| CN-114478549-B | Pyrazolo [3,4-d ] pyrrolo [1,2-a ] pyrimidinone arylene derivative and application thereof | 中国科学院新疆理化技术研究所 | 2023-06-23 | — | — | CN | disclosed |
| CN-114478549-A | Pyrazolo [3,4-d ] pyrrolo [1,2-a ] pyrimidone arylene derivative and application thereof | 中国科学院新疆理化技术研究所 | 2022-05-13 | — | — | CN | disclosed |