Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 4/20 | 0.41 |
| ▸ | AKT1 | P31749 | 3/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14783689 | 1.00 | BRAF (0.44) | BRAFEPHX2KCNQ3KCNQ2MTOR | |
| SCHEMBL29591393 | 0.94 | BRAF (0.51) | BRAFEPHX2KCNQ3KCNQ2MTOR | |
| SCHEMBL14783494 | 0.94 | BRAF (0.51) | BRAFEPHX2KCNQ3KCNQ2MTOR | |
| SCHEMBL14783836 | 0.93 | EPHX2 (0.45) | BRAFEPHX2KCNQ3KCNQ2MTOR | |
| SCHEMBL29591695 | 0.93 | EPHX2 (0.45) | BRAFEPHX2KCNQ3KCNQ2MTOR | |
| SCHEMBL14783387 | 0.92 | AKT1 (0.49) | BRAFEPHX2KCNQ3KCNQ2MTOR | |
| SCHEMBL29590933 | 0.92 | AKT1 (0.49) | BRAFEPHX2KCNQ3KCNQ2MTOR | |
| SCHEMBL29590395 | 0.92 | PIK3CA (0.47) | EPHX2KCNQ3KCNQ2MTORAKT1 | |
| SCHEMBL14783539 | 0.92 | PIK3CA (0.47) | EPHX2KCNQ3KCNQ2MTORAKT1 | |
| SCHEMBL14783277 | 0.91 | LMNA (0.50) | EPHX2KCNQ3KCNQ2MTORAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403531-A | Chemical entities, compositions, and methods as kinase inhibitors | 润新生物公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-108794411-B | Certain chemical entities, compositions, and methods | 润新生物公司 | 2022-06-07 | — | — | CN | disclosed |