Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PPM1A | P35813 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | EPM2A | O95278 | 1/20 | 0.32 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | PLG | P00747 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17839829 | 1.00 | CYP2A6 (0.38) | CYP2A6LMNAMAPTEPAS1PDPK1 | |
| SCHEMBL20520481 | 0.86 | LSS (0.35) | LMNAMAPTEPAS1PPM1AXDH | |
| SCHEMBL23088400 | 0.79 | CYP2A6 (0.38) | CYP2A6EPAS1L3MBTL1HTT | |
| SCHEMBL29792735 | 0.79 | CYP2A6 (0.38) | CYP2A6EPAS1L3MBTL1HTT | |
| SCHEMBL2967038 | 0.76 | EPAS1 (0.38) | CYP2A6MAPTEPAS1PDPK1JAK2 | |
| SCHEMBL15898942 | 0.73 | CA2 (0.35) | CYP2A6EPAS1CA2 | |
| SCHEMBL19141271 | 0.73 | KDM4E (0.50) | CYP2A6MAPTEPAS1 | |
| SCHEMBL30481262 | 0.72 | EPAS1 (0.38) | CYP2A6LMNAEPAS1PDPK1JAK2 | |
| SCHEMBL10164894 | 0.72 | EPAS1 (0.38) | CYP2A6LMNAEPAS1PDPK1JAK2 | |
| Hydrochloric Acid SCHEMBL10465963 | 0.70 | CYP11B1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041238-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2022-08-17 | — | — | EP | disclosed |
| CN-114502168-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-13 | — | — | CN | disclosed |