Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.80 |
| ▸ | MAPK12 | P53778 | 12/20 | 0.80 |
| ▸ | HCK | P08631 | 11/20 | 0.80 |
| ▸ | TNF | P01375 | 3/20 | 0.80 |
| ▸ | CIT | O14578 | 1/20 | 0.68 |
| ▸ | MUSK | O15146 | 1/20 | 0.68 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.68 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.68 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.68 |
| ▸ | STK10 | O94804 | 1/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.68 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.68 |
| ▸ | ABL1 | P00519 | 1/20 | 0.68 |
| ▸ | EGFR | P00533 | 1/20 | 0.68 |
| ▸ | RAF1 | P04049 | 1/20 | 0.68 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.68 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.68 |
| ▸ | PRKCB | P05771 | 1/20 | 0.68 |
| ▸ | LCK | P06239 | 1/20 | 0.68 |
| ▸ | FYN | P06241 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL300495 | 1.00 | MAPK14 (0.80) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL29593358 | 0.89 | MAPK14 (1.00) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL295686 | 0.89 | MAPK14 (1.00) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL2408004 | 0.88 | MAPK14 (1.00) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL6680086 | 0.88 | MAPK14 (0.72) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL2309509 | 0.87 | MAPK14 (0.88) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL28466145 | 0.87 | MAPK14 (0.72) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL6298579 | 0.87 | MAPK14 (0.79) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL2554222 | 0.86 | MAPK14 (1.00) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL365566 | 0.86 | MAPK14 (0.78) | MAPK14MAPK12HCKTNFCIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114748622-B | P38 kinase inhibitors reduce DUX4 and downstream gene expression and treat FSHD | 弗尔康医疗公司 | 2024-09-24 | — | — | CN | disclosed |
| CN-114732910-B | P38 kinase inhibitors reduce DUX4 and downstream gene expression and treat FSHD | 弗尔康医疗公司 | 2024-08-23 | — | — | CN | disclosed |
| CN-114748622-A | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD | 弗尔康医疗公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-114732910-A | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-07-12 | — | — | CN | disclosed |
| CN-111601593-B | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-04-15 | — | — | CN | disclosed |