Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 19/20 | 0.54 |
| ▸ | CDK2 | P24941 | 19/20 | 0.54 |
| ▸ | CCND1 | P24385 | 10/20 | 0.54 |
| ▸ | CDK6 | Q00534 | 10/20 | 0.54 |
| ▸ | CDK4 | P11802 | 8/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.54 |
| ▸ | CDK9 | P50750 | 7/20 | 0.54 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.52 |
| ▸ | CCND3 | P30281 | 2/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27061752 | 0.84 | CDK2 (0.58) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL30804793 | 0.84 | CDK2 (0.58) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL26340819 | 0.81 | CCNE1 (0.59) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22977477 | 0.74 | CCNE1 (0.68) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL26941919 | 0.74 | CCNE1 (0.62) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL31538947 | 0.74 | CDK2 (0.62) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL26340844 | 0.72 | CCNE1 (0.60) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL26340941 | 0.72 | CCNE1 (0.60) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL26340940 | 0.72 | CCNE1 (0.60) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL29594774 | 0.72 | CDK2 (0.56) | CCNE1CDK2CCND1CDK6CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114394966-A | Pyridopyrimidinone CDK2/4/6 inhibitors | 辉瑞公司 | 2022-04-26 | — | — | CN | disclosed |