Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | THPO | P40225 | 2/20 | 0.38 |
| ▸ | GMNN | O75496 | 2/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | STAT6 | P42226 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL28815467 | 0.94 | CYP19A1 (0.36) | LMNAMAPK1TP53NFKB1THPO | |
| SCHEMBL556690 | 0.92 | CYP19A1 (0.38) | CYP19A1 | |
| Formic Acid SCHEMBL28540793 | 0.89 | CYP19A1 (0.36) | CYP19A1 | |
| SCHEMBL36696 | 0.75 | TFPI2 (0.34) | LMNAMAPK1TP53NFKB1THPO | |
| SCHEMBL11771538 | 0.74 | CYP19A1 (0.35) | CYP19A1 | |
| SCHEMBL28644478 | 0.73 | LMNA (0.37) | LMNAMAPK1TP53NFKB1THPO | |
| SCHEMBL2537579 | 0.72 | CYP19A1 (0.33) | LMNATP53NFKB1THPOGMNN | |
| SCHEMBL28760355 | 0.72 | LMNA (0.30) | LMNATP53NFKB1THPOGMNN | |
| SCHEMBL9900814 | 0.72 | — | — | |
| SCHEMBL14114628 | 0.71 | PDE4D (0.34) | CYP2C19CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1719789-B1 | Hyperbranched polymer and cycloaliphatic epoxy resin thermosets | DELPHI TECH INC (US) | 2008-10-01 | — | — | EP | claimed |
| US-20060252892-A1 | Hyperbranched polymer and cycloaliphatic epoxy resin thermosets | INTEL CORPORATION | 2006-11-09 | — | — | US | claimed |
| EP-1719789-A1 | Hyperbranched polymer and cycloaliphatic epoxy resin thermosets | Delphi Technologies, Inc. (US) | 2006-11-08 | — | — | EP | claimed |
| US-7754824-B2 | Dendritic polyol, cycloaliphatic epoxy resin and cationic initiator | DELPHI TECHNOLOGIES, INC. (US) | 2010-07-13 | — | — | US | disclosed |
| US-20090082528-A1 | HYPERBRANCHED POLYMER AND CYCLOALIPHATIC EPOXY RESIN THERMOSETS | INTEL CORPORATION | 2009-03-26 | — | — | US | disclosed |
| EP-1719789-B1 | Hyperbranched polymer and cycloaliphatic epoxy resin thermosets | DELPHI TECH INC (US) | 2008-10-01 | — | — | EP | disclosed |
| US-20060252892-A1 | Hyperbranched polymer and cycloaliphatic epoxy resin thermosets | INTEL CORPORATION | 2006-11-09 | — | — | US | disclosed |
| EP-1719789-A1 | Hyperbranched polymer and cycloaliphatic epoxy resin thermosets | Delphi Technologies, Inc. (US) | 2006-11-08 | — | — | EP | disclosed |
| US-5364691-A | Alk-1-enyloxy carbonates | ISP INVESTMENTS INC. (US) | 1994-11-15 | — | — | US | disclosed |