Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.49 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.49 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.49 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.49 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.49 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.49 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.49 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20324715 | 1.00 | HRH3 (0.50) | HRH3ROCK1ROCK2PRKACAPRKCD | |
| SCHEMBL20324756 | 0.92 | HRH3 (0.51) | HRH3ROCK1ROCK2PRKACAPRKCD | |
| SCHEMBL10683820 | 0.88 | ROCK1 (0.52) | HRH3ROCK1ROCK2PRKACAPRKCD | |
| SCHEMBL8597524 | 0.86 | HRH3 (0.49) | HRH3PBRM1 | |
| SCHEMBL21461282 | 0.80 | HRH3 (0.51) | HRH3ROCK1ROCK2PRKACAPRKCD | |
| SCHEMBL20324758 | 0.79 | HRH3 (0.53) | HRH3PARP1 | |
| SCHEMBL1794738 | 0.78 | ROCK1 (0.54) | HRH3ROCK1ROCK2PRKACAPRKCD | |
| SCHEMBL29595567 | 0.78 | ROCK1 (0.45) | HRH3ROCK1ROCK2PRKACAPRKCD | |
| SCHEMBL20324926 | 0.78 | ROCK1 (0.45) | HRH3ROCK1ROCK2PRKACAPRKCD | |
| SCHEMBL21461296 | 0.77 | MAOA (0.52) | HRH3ROCK1ROCK2PRKACAPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11319298-B2 | Heteroaryl piperidine ether allosteric modulators of the M4 muscarinic acetylcholine receptor | MERCK SHARP & DOHME CORP. (US) | 2022-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11319298-B2 | Heteroaryl piperidine ether allosteric modulators of the M4 muscarinic acetylcholine receptor | CHRM4, CHRM2, CHRM5 | HRH3 112/4885ROCK1 2275/4885ROCK2 1984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.