Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | AVPR2 | P30518 | 5/20 | 0.61 |
| ▸ | OXTR | P30559 | 5/20 | 0.61 |
| ▸ | AVPR1A | P37288 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.55 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.55 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24499929 | 1.00 | POLB (0.61) | POLBHSD17B10AVPR2OXTRAVPR1A | |
| SCHEMBL27197579 | 0.89 | POLB (0.70) | POLBHSD17B10AVPR2OXTRAVPR1A | |
| SCHEMBL29598193 | 0.89 | POLB (0.70) | POLBHSD17B10AVPR2OXTRAVPR1A | |
| SCHEMBL29597109 | 0.88 | POLB (0.57) | POLBHSD17B10AVPR2OXTRAVPR1A | |
| SCHEMBL29598005 | 0.87 | POLB (0.64) | POLBHSD17B10AVPR2OXTRAVPR1A | |
| SCHEMBL27197599 | 0.87 | POLB (0.64) | POLBHSD17B10AVPR2OXTRAVPR1A | |
| SCHEMBL27197571 | 0.87 | POLB (0.70) | POLBHSD17B10AVPR2OXTRAVPR1A | |
| SCHEMBL29598108 | 0.87 | POLB (0.70) | POLBHSD17B10AVPR2OXTRAVPR1A | |
| SCHEMBL24500003 | 0.84 | ALDH1A1 (0.70) | POLBHSD17B10AVPR2OXTRAVPR1A | |
| SCHEMBL29597115 | 0.84 | ALDH1A1 (0.70) | POLBHSD17B10AVPR2OXTRAVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4255902-A1 | 2,3-DIHYDRO-4H-BENZO[B][1,4]OXAZIN-4-YL)(5-(PHENYL)-PYRIDIN-3-YL)METHANONE DERIVATIVES AND SIMILAR COMPOUNDS AS CYP11A1 INHIBITORS FOR THE TREATMENT OF PROSTATE CANCER | Orion Corporation (FI) | 2023-10-11 | — | — | EP | claimed |
| WO-2022117920-A1 | 2,3-DIHYDRO-4H-BENZO[B][1,4]OXAZIN-4-YL)(5-(PHENYL)-PYRIDIN-3-YL)METHANONE DERIVATIVES AND SIMILAR COMPOUNDS AS CYP11A1 INHIBITORS FOR THE TREATMENT OF PROSTATE CANCER | ORION CORPORATION (FI) | 2022-06-09 | — | — | WO | claimed |
| EP-4255902-A1 | 2,3-DIHYDRO-4H-BENZO[B][1,4]OXAZIN-4-YL)(5-(PHENYL)-PYRIDIN-3-YL)METHANONE DERIVATIVES AND SIMILAR COMPOUNDS AS CYP11A1 INHIBITORS FOR THE TREATMENT OF PROSTATE CANCER | Orion Corporation (FI) | 2023-10-11 | — | — | EP | disclosed |
| WO-2022117920-A1 | 2,3-DIHYDRO-4H-BENZO[B][1,4]OXAZIN-4-YL)(5-(PHENYL)-PYRIDIN-3-YL)METHANONE DERIVATIVES AND SIMILAR COMPOUNDS AS CYP11A1 INHIBITORS FOR THE TREATMENT OF PROSTATE CANCER | ORION CORPORATION (FI) | 2022-06-09 | — | — | WO | disclosed |