Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 20/20 | 0.69 |
| ▸ | JAK1 | P23458 | 19/20 | 0.69 |
| ▸ | JAK2 | O60674 | 18/20 | 0.69 |
| ▸ | JAK3 | P52333 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22855942 | 1.00 | TYK2 (0.69) | TYK2JAK1JAK2JAK3 | |
| SCHEMBL29414167 | 0.88 | TYK2 (0.52) | TYK2JAK1JAK2JAK3 | |
| SCHEMBL22855941 | 0.88 | TYK2 (0.52) | TYK2JAK1JAK2JAK3 | |
| SCHEMBL22856034 | 0.88 | TYK2 (0.52) | TYK2JAK1JAK2JAK3 | |
| SCHEMBL22855940 | 0.81 | JAK2 (0.67) | TYK2JAK1JAK2JAK3 | |
| SCHEMBL17545397 | 0.78 | TYK2 (0.70) | TYK2JAK1JAK2JAK3 | |
| Hydrochloric Acid SCHEMBL17512510 | 0.77 | TYK2 (0.69) | TYK2JAK1JAK2JAK3 | |
| Hydrochloric Acid SCHEMBL17512666 | 0.76 | TYK2 (0.69) | TYK2JAK1JAK2JAK3 | |
| SCHEMBL29414214 | 0.75 | AURKA (0.48) | TYK2JAK1JAK2 | |
| SCHEMBL22856004 | 0.74 | TYK2 (0.59) | TYK2JAK1JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3990449-A1 | HETEROCYCLIC COMPOUNDS FOR MEDIATING TYROSINE KINASE 2 ACTIVITY | Guangzhou InnoCare Pharma Tech Co., Ltd. (CN) | 2022-05-04 | — | — | EP | disclosed |