Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15882795 | 1.00 | FFAR1 (0.31) | FFAR1GSK3AGSK3BDGAT1PDGFRB | |
| SCHEMBL18403356 | 0.88 | PDGFRB (0.32) | FFAR1GSK3AGSK3BDGAT1PDGFRB | |
| SCHEMBL15882578 | 0.81 | DGAT1 (0.32) | DGAT1 | |
| SCHEMBL21463280 | 0.78 | — | — | |
| SCHEMBL3514989 | 0.75 | FFAR1 (0.35) | FFAR1GSK3AGSK3BDGAT1PDGFRB | |
| SCHEMBL16283528 | 0.74 | BACE1 (0.35) | PRMT5WDR77 | |
| SCHEMBL16277514 | 0.74 | BACE1 (0.35) | PRMT5WDR77 | |
| SCHEMBL25316750 | 0.72 | NPC1 (0.35) | — | |
| SCHEMBL30506908 | 0.72 | NPC1 (0.35) | — | |
| SCHEMBL31085612 | 0.72 | MARK3 (0.39) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3268373-B1 | TRICYCLIC DLK INHIBITORS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2022-04-27 | — | — | EP | disclosed |