Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24371611 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1KMT2AALDH1A1POLB | |
| SCHEMBL29599304 | 0.87 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2AALDH1A1POLB | |
| SCHEMBL29599533 | 0.87 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2AALDH1A1POLB | |
| SCHEMBL24371870 | 0.87 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2AALDH1A1POLB | |
| SCHEMBL8421994 | 0.83 | ALDH1A1 (0.55) | SMN1; SMN2MEN1KMT2AALDH1A1POLB | |
| SCHEMBL6551228 | 0.79 | TSHR (0.56) | SMN1; SMN2MEN1KMT2AALDH1A1POLB | |
| SCHEMBL16957915 | 0.77 | ALDH1A1 (0.50) | SMN1; SMN2MEN1KMT2AALDH1A1POLB | |
| SCHEMBL1032670 | 0.77 | ALDH1A1 (0.68) | SMN1; SMN2MEN1KMT2AALDH1A1POLB | |
| SCHEMBL206164 | 0.77 | TSHR (0.58) | SMN1; SMN2MEN1KMT2AALDH1A1POLB | |
| SCHEMBL2521491 | 0.77 | HPGD (0.52) | SMN1; SMN2MEN1KMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232431-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH LPA RECEPTOR ACTIVITY | Lhotse Bio, Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022083703-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH LPA RECEPTOR ACTIVITY | LHOTSE BIO, INC. (US) | 2022-04-28 | — | — | WO | disclosed |