Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4706466 | 0.75 | — | — | |
| SCHEMBL14580328 | 0.54 | KDM4E (0.35) | KDM4EGAA | |
| SCHEMBL17690045 | 0.53 | DGAT1 (0.35) | KDM4EGAA | |
| SCHEMBL29060486 | 0.52 | PI4KA (0.34) | — | |
| SCHEMBL29044216 | 0.52 | ADORA2A (0.36) | — | |
| SCHEMBL23240695 | 0.52 | ADORA2A (0.33) | KDM4EGAA | |
| SCHEMBL23675955 | 0.51 | ADORA2A (0.36) | KDM4EGAA | |
| Vitamin B4 SCHEMBL4257555 | 0.51 | KDR (0.43) | — | |
| SCHEMBL9413252 | 0.51 | KDR (0.56) | KDM4EGAA | |
| SCHEMBL12844194 | 0.49 | KDR (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3268373-B1 | TRICYCLIC DLK INHIBITORS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2022-04-27 | — | — | EP | disclosed |